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メカノトランスダクションによる心臓血管発生制御​

福井 一、中嶋 洋行、望月 直樹

医学のあゆみ 2022 Dec., 283;1298-1302​

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​​Cardiac hemodynamics and ventricular stiffness of sea-run cherry salmon (Oncorhynchus masou masou) differ critically from those of landlocked masu salmon

Yuu Usui, Misaki Kimoto, Akira Hanashima, Ken Hashimoto, Satoshi Mohri

PLoS One. 2022 Nov 4;17(11):e0267264.  doi: 10.1371/journal.pone.0267264. eCollection 2022.

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機械的な力に応じた生体電気シグナル伝達心臓弁となる細胞運命を制御する

福井一

臨床免疫・アレルギー科 2022; 78(3)334-340

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Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis

Hélène Vignes, Christina Vagena-Pantoula, Mangal Prakash, Hajime Fukui, Caren Norden, Naoki Mochizuki, Florian Jug, Julien Vermot

Dev Cell. 2022 Mar 14;57(5):598-609.e5. doi: 10.1016/j.devcel.2022.02.011. Epub 2022 Mar 3.

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Postnatal expression of cell cycle promoter Fam64a  causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15

Ken Hashimoto, Aya Kodama, Momoko Ohira, Misaki Kimoto, Reiko Nakagawa, Yuu Usui, Yoshihiro Ujihara, Akira Hanashima, Satoshi Mohri

iScience. 2022 Apr 30;25(5):104337.  doi: 10.1016/j.isci.2022.104337.  eCollection 2022 May 20.

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「力」に応答した生体電気シグナルによる心臓弁形成メカニズム

福井 一

実験医学 2022 Apr., 40;925-928.

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Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling

Renee Wei-Yan Chow, Hajime Fukui, Wei Xuan Chan, Kok Soon Justin Tan, Stéphane Roth, Anne-Laure Duchemin, Nadia Messaddeq, Hiroyuki Nakajima, Fei Liu, Nathalie Faggianelli-Conrozier, Andrey S Klymchenko, Yap Choon Hwai, Naoki Mochizuki, Julien Vermot

PLoS Biol. 2022 Jan 14;20(1):e3001505. doi: 10.1371/journal.pbio.3001505.eCollection 2022 Jan.

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Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces

Hajime Fukui, Renee Wei-Yan Chow, Jing Xie, Yoke Yin Foo, Choon Hwai Yap, Nicolas Minc, Naoki Mochizuki, Julien Vermot

Science. 2021 Oct 15;374(6565):351-354. doi: 10.1126/science.abc6229. Epub 2021 Oct 14.

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Role of the Connexin C-terminus in skin pattern formation of Zebrafish

Yuu Usui, Masakatsu Watanabe

BBA Adv. 2021 Mar 17:1:100006.  doi: 10.1016/j.bbadva.2021.100006.  eCollection 2021.

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疾患動物モデルとしてのゼブラフィッシュモデル動物の作製と利用

福井 一, 迫 圭輔, 望月 直樹

循環器疾患 2021下巻 2021: 第3章 第3節 175-184.

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一次繊毛と心臓形成―心臓に毛が生えている意義とは―

福井 一

腎と透析 2019 Nov., 87;729-734.

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[Review] The cilium as a force sensor-myth versus reality

Rita R Ferreira, Hajime Fukui, Renee Chow, Andrej Vilfan, Julien Vermot

J Cell Sci. 2019 Jul 30;132(14):jcs213496.  doi: 10.1242/jcs.213496.

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Chiral Cilia Orientation in the Left-Right Organizer

Rita R Ferreira, Guillaume Pakula, Lhéanna Klaeyle, Hajime Fukui, Andrej Vilfan, Willy Supatto, Julien Vermot

Cell Rep. 2018 Nov 20;25(8):2008-2016.e4.  doi: 10.1016/j.celrep.2018.10.069.

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The minimal gap-junction network among melanophores and xanthophores required for stripe pattern formation in zebrafish

Yuu Usui, Toshihiro Aramaki, Shigeru Kondo, Masakatsu Watanabe

Development. 2019 Nov 15;146(22):dev181065.  doi: 10.1242/dev.181065.

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Melanophore multinucleation pathways in zebrafish

Yuu Usui, Shigeru Kondo, Masakatsu Watanabe

Dev Growth Differ. 2018 Sep;60(7):454-459.  doi: 10.1111/dgd.12564.  Epub 2018 Aug 7.

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Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish

Hajime Fukui, Takahiro Miyazaki, Renee Wei-Yan Chow, Hiroyuki Ishikawa, Hiroyuki Nakajima, Julien Vermot, Naoki Mochizuki

Elife. 2018 May 29:7:e29106.  doi: 10.7554/eLife.29106.

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A New Secretory Peptide of Natriuretic Peptide Family, Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction​

Takahiro Miyazaki, Kentaro Otani, Ayano Chiba, Hirohito Nishimura, Takeshi Tokudome, Haruko Takano-Watanabe, Ayaka Matsuo, Hiroyuki Ishikawa, Keiko Shimamoto, Hajime Fukui, Yugo Kanai, Akihiro Yasoda, Soshiro Ogata, Kunihiro Nishimura, Naoto Minamino, Naoki Mochizuki 

Circ Res. 2018 Mar 2;122(5):742-751.  doi: 10.1161/CIRCRESAHA.117.312624.  Epub 2018 Jan 11.

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​心臓形成と一次繊毛

福井 一

実験医学 2018 Apr., 36;955-959.

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心臓・血管の初期発生メカニズムの解明
福井 一、千葉 彩乃、宮崎 敬大、石川 博之、島本 恵子、中嶋 洋行、望月 直樹

循環器病研究の進歩 2017 Nov., 38;75-83.

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Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance

Hiroyuki Nakajima, Kimiko Yamamoto, Sobhika Agarwala, Kenta Terai, Hajime Fukui, Shigetomo Fukuhara, Koji Ando, Takahiro Miyazaki, Yasuhiro Yokota, Etienne Schmelzer, Heinz-Georg Belting, Markus Affolter, Virginie Lecaudey, Naoki Mochizuki

Dev Cell. 2017 Mar 27;40(6):523-536.e6.  doi: 10.1016/j.devcel.2017.02.019.

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Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis

Hajime Fukui, Ayano Chiba, Takahiro Miyazaki, Haruko Takano, Hiroyuki Ishikawa, Toyonori Omori, Naoki Mochiuzki

Korean Circ J. 2017 Mar;47(2):160-167.  doi: 10.4070/kcj.2016.0280. Epub 2017 Mar 13.

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Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish

Ayano Chiba, Haruko Watanabe-Takano, Kenta Terai, Hajime Fukui, Takahiro Miyazaki, Mami Uemura, Hisashi Hashimoto, Masahiko Hibi, Shigetomo Fukuhara, Naoki Mochizuki

Development. 2017 Jan 15;144(2):334-344.  doi: 10.1242/dev.143354.  Epub 2016 Dec 19.

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Identification of a highly immunogenic mouse breast cancer sub cell line, 4T1-S

Hirotake Abe, Haruka Wada, Muhammad Baghdadi , Sayaka Nakanishi, Yuu Usui, Takahiro Tsuchikawa, Toshiaki Shichinohe, Satoshi Hirano, Ken-Ichiro Seino

Hum Cell. 2016 Apr;29(2):58-66.  doi: 10.1007/s13577-015-0127-1.  Epub 2016 Feb 8.

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Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish

Koji Ando, Shigetomo Fukuhara, Nanae Izumi, Hiroyuki Nakajima, Hajime Fukui, Robert N Kelsh, Naoki Mochizuki

Development. 2016 Apr 15;143(8):1328-39.  doi: 10.1242/dev.132654.  Epub 2016 Mar 7.

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S1P-S1p2 Signaling in Cardiac Precursor Cells Migration

Hajime Fukui, Shigetomo Fukuhara, Naoki Mochizuki, Toshio Nakanishi, Roger R. Markwald, H.Scott Baldwin, Bradley B. Keller, Deepak Srivastava, Hiroyuki Yamagishi, editors.

In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 14. 2016 Jun 25.

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Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cells

Masatoshi Kanda, Hiroyuki Yamanaka, Satoshi Kojo, Yuu Usui, Hiroaki Honda, Yusuke Sotomaru, Michishige Harada, Masaru Taniguchi, Nao Suzuki, Tatsuya Atsumi, Haruka Wada, Muhammad Baghdadi, Ken-Ichiro Seino

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3394-402.  doi: 10.1073/pnas.1604178113. Epub 2016 May 25.

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PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination

Jun-Dal Kim, Kyung-Eui Park, Junji Ishida, Koichiro Kako, Juri Hamada, Shuichi Kani, Miki Takeuchi, Kana Namiki, Hajime Fukui, Shigetomo Fukuhara, Masahiko Hibi, Makoto Kobayashi, Yasunori Kanaho, Yoshitoshi Kasuya, Naoki Mochizuki, Akiyoshi Fukamizu

Sci Adv. 2015 Dec 4;1(11):e1500615.  doi: 10.1126/sciadv.1500615.  eCollection 2015 Dec.

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Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer

Shintaro Takeuchi, Muhammad Baghdadi, Takahiro Tsuchikawa, Haruka Wada, Toru Nakamura, Hirotake Abe, Sayaka Nakanishi, Yuu Usui, Kohtaro Higuchi, Mizuna Takahashi, Kazuho Inoko, Syoki Sato, Hironobu Takano, Toshiaki Shichinohe, Ken-ichiro Seino, Satoshi Hirano

Cancer Res. 2015 Jul 1;75(13):2629-40.  doi: 10.1158/0008-5472.CAN-14-2921. Epub 2015 May 7.

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Looking back and moving forward: recent advances in understanding of cardiovascular development by imaging of zebrafish

Shigetomo Fukuhara, Hajime Fukui, Yuki Wakayama, Koji Ando, Hiroyuki Nakajima, Naoki Mochizuki

Dev Growth Differ. 2015 May;57(4):333-40.  doi: 10.1111/dgd.12210.  Epub 2015 Apr 10.

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β-Catenin-dependent transcription is central to Bmp-mediated formation of venous vessels

Takeru Kashiwada, Shigetomo Fukuhara, Kenta Terai, Toru Tanaka, Yuki Wakayama, Koji Ando, Hiroyuki Nakajima, Hajime Fukui, Shinya Yuge, Yoshinobu Saito, Akihiko Gemma, Naoki Mochizuki

Development. 2015 Feb 1;142(3):497-509.  doi: 10.1242/dev.115576.  Epub 2015 Jan 6.

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心臓発生における転写共役因子 Yap の機能

福井 一、望月 直樹

医学のあゆみ 2014 Nov., 251;410-415

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S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish

Hajime Fukui, Kenta Terai, Hiroyuki Nakajima, Ayano Chiba, Shigetomo Fukuhara, Naoki Mochizuki

Dev Cell. 2014 Oct 13;31(1):128-36.  doi: 10.1016/j.devcel.2014.08.014.

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The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish

Hajime Fukui, Dai Shiba, Kazuhide Asakawa, Koichi Kawakami, Takahiko Yokoyama

FEBS Lett. 2012 Jul 30;586(16):2273-9.  doi: 10.1016/j.febslet.2012.05.064.  Epub 2012 Jun 8.

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A three-step process of Nphp3 ciliary localization

Shiba D, Nakata K, Fukui H, Kobayashi D, Yokoyama T

Cilia. 2012 Nov 16; 1:46. Proceedings of the First International Cilia in Development and Disease Scientific Conference (2012)

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The herbal medicine compound falcarindiol from Notopterygii Rhizoma suppresses dendritic cell maturation

Seika Mitsui, Kan Torii, Hajime Fukui, Kunio Tsujimura, Akira Maeda, Mitsuhiko Nose, Akito Nagatsu, Hajime Mizukami, Akimichi Morita

J Pharmacol Exp Ther. 2010 Jun;333(3):954-60.  doi: 10.1124/jpet.109.162305.  Epub 2010 Mar 9.

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Noncanonical activity of seryl-tRNA synthetase is involved in vascular development 

Hajime Fukui, Ryuki Hanaoka, Atsuo Kawahara

Circ Res. 2009 Jun 5;104(11):1253-9.  doi: 10.1161/CIRCRESAHA.108.191189.  Epub 2009 May 7.

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The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors

Atsuo Kawahara, Tsuyoshi Nishi, Yu Hisano, Hajime Fukui, Akihito Yamaguchi, Naoki Mochizuki

Science. 2009 Jan 23;323(5913):524-7.  doi: 10.1126/science.1167449.  Epub 2008 Dec 11.

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Novel functions of herbal medicines in dendritic cells: role of Amomi Semen in tumor immunity

Hajime Fukui, Seika Mitsui, Nobue Harima, Mitsuhiko Nose, Kunio Tsujimura, Hajime Mizukami, Akimichi Morita

Microbiol Immunol. 2007;51(11):1121-33.  doi: 10.1111/j.1348-0421.2007.tb03998.x.